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What is N-Methyltyramine?

what is N-Methyltyramine
Last modified: January 15th, 2019 01:44 am

We’re going to go ahead and assume that most of our readers don’t know the answer to “What is N-Methyltyramine”.  Even for the most hardcore supplement users, you probably aren’t going to be overly familiar with n-methyltyramine.  As if n-methyltyramine isn’t hard enough to say, it’s actually an abbreviated version of what you’re actually talking about, which is 4-hydroxy-N-methylphenethylamine.  Let’s agree to calling it NMT for now.

NMT is a human trace amine.  Basically, it’s a neuromodulator substance found in plants that tends to be similar to our neurotransmitters substances.  Used almost exclusively in pre workout and fat burning supplements, NMT is comparable to octopamine, hordenine, and synephrine.

Where Does N-Methyltyramine Come From?

Found in the barks, roots, shoots, and leaves of a large variety of plants, NMT is something humans have been ingesting since the dawn of human kind.  Originally found in barley, it wasn’t uncommon for people to gain high levels of NMT through alcohol consumption.  Barley has always been a common ingredient in meads and beers around the world.  Imagine getting drunk and helping your weight loss goals at the same time!  It’s a shame all the other stuff, like carbohydrates, will counteract the “good” found in beer [1].

Today, NMT is extracted out of plants in giant plant farms.  Since NMT is a bi-product of the organics, it’s an easy way for farms to make extra cash before selling off their herbal crops to other manufacturers for other uses.  The extract can be costly but is a lucrative business that will certainly pay for itself over time.

Why do We Care?

Vaxxen, like many of the industry leading fitness supplement manufacturers, leverages NMT for the stimulant properties.  Using NMT can directly improve workout performance through mental means.  Elevated NMT levels stimulates the release of noradrenaline, improving focus.  Not only are your mental capabilities more refined and honed, but your heartbeat increases and the entire cardiovascular system becomes more effective.  Some studies have even shown wild improvement in mood and energy after NMT supplementation.

When to Ingest?

If you’re looking for something to give you the extra kick needed after a long day to power through the toughest of workouts, we suggest looking for supplements that utilize NMT.  Most pre workout and fat burn mixes that contain NMT, like Cinerate, should be taken 30 to 60 minutes prior to the start of a workout.  It won’t matter whether you’re hitting the weights or going for an extended cardio-workout, the NMT will make your body kick in to overdrive by producing noradrenaline, allowing the other substances in the Cinerate mix to further enhance your system to maximize the workout.


Stacking NMT

Be sure to mix maximize the effects of your NMT if you can, allowing you to get the most bang for your buck.  We suggest stacking NMT with BCAA’s and pump boosters if you’re trying to gain muscle mass while burning fat.  If you’re not too concerned with the muscle gains and want to focus on the thin or lean look, make sure you stack your NMT with other fat burning supplements including caffeine [2].  In either scenario, make sure you follow up your workouts with a good protein shake!


  1. Stohs SJ1, Hartman MJ.
    A review of the receptor binding and pharmacological effects of N-methyltyramine.
    Phytother Res. 2015 Jan;29(1):14-6. doi: 10.1002/ptr.5231. Epub 2014 Oct 2.
  2. Milan Holečekcorresponding author
    Branched-chain amino acids in health and disease: metabolism, alterations in blood plasma, and as supplements
    Nutr Metab (Lond). 2018; 15: 33.
    Published online 2018 May 3. doi: 10.1186/s12986-018-0271-1

SR Content Strategist & Fitness Expert

Matt Weik, the owner of Weik Fitness, LLC, is a well-respected fitness expert/author/podcaster with a global following. His work has been featured in nearly 100 fitness magazines (Flex Magazine, Men’s Muscle & Health Magazine, Oxygen Magazine), 2,000+ websites, as well as having numerous books and audiobooks that are published.  Matt Weik graduated from Penn State University with a degree in Kinesiology. He is a certified strength and conditioning specialist, personal trainer, and sports nutritionist. Matt is a member of the supplement expert panel at the Awards 2018.

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