N-Methyltyramine: Uses, Benefits, and Side Effects

N-Methyltyramine

What is N-Methyltyramine?

N-methyltyramine (4-hydroxy-N-methylphenethylamine), known simply as “NMT,” is an organic trace amine found naturally in the human body and in cocoa, barley roots (and thus beer), Citrus aurantium, and many other plants.[1]

Chemically speaking, N-methyltyramine is a derivative of phenethylamine (PEA) – a nootropic that has become increasingly popular in recent years due to its stimulating properties in the central nervous system

However, the body doesn’t readily produce NMT from PEA; instead, NMT is made in minute amounts from the metabolism of L-tyrosine (and subsequently p-tyramine).

Nevertheless, the physiological effects of NMT are quite similar to PEA. NMT is a nervous system stimulant that works as a neuromodulator (primarily acting on noradrenaline) and consequently is surmised to promote fat loss.[2]

Used almost exclusively in pre-workout and thermogenic supplements, NMT is comparable to ingredients like octopamine, hordenine, and synephrine.

Where Does N-Methyltyramine Come From?

Most of the NMT in the body comes from the consumption of plant foods that contain p-tyramine and/or NMT itself. Examples of common plant foods that contain p-tyramine and/or NMT are barley, cocoa, and citrus fruits (grapefruit, oranges, etc.).

Barley is a common grain used in making beer and malt liquor, meaning alcohol is another source of dietary NMT. However, the amount of NMT in a typical beer is negligible – as low as three milligrams per pint (473 mL).[3]

In other words, don’t get the idea that drinking two pints of beer every night is somehow going to give you enough NMT to lose weight because that’s an absurd notion. If you really want to reap the benefits of NMT, the most practical and efficacious option is to supplement with it.

On that note, let’s take a deeper look at the benefits of N-methyltyramine and the best way to use it for enhancing mental and physical performance.

N-Methyltyramine Benefits: Mental and Physical

NMT supplementation is undeniably effective for bodybuilding enthusiasts and athletes alike.  Since N-methyltyramine is a neuromodulator, the main benefits of NMT supplementation are mental changes, such as enhanced motivation, increased focus, and a greater sense of urgency.

Intuitively, the mental benefits of NMT translate to physical benefits as well, like better athletic performance, elevated thermogenesis (calorie expenditure), and thus, improved fat loss.

So, how does NMT work physiologically to promote mental and physical performance?

N-Methyltyramine Mental Benefits

NMT is largely adrenergic in nature, meaning it modulates the activity of noradrenaline and adrenaline – two catecholamines that are responsible for the fight-or-flight response (which is governed by the sympathetic nervous system).

Have you ever wondered where that rush of energy and seemingly superhero-like mental changes comes from when you’re in a do-or-die situation? That’s all the adrenaline and noradrenaline in your body telling you to either run or stand your ground.

Imagine you just robbed a bank and you hear the cop car sirens whirring closer to your location. Chances are you’re going to run, and run faster than you ever thought you were capable of because of all the catecholamines flowing through your veins.

This is analogous to the effects of NMT. In fact, some animal research suggests that NMT can increase the release of norepinephrine by as much as 36% compared to placebo.[4] (Granted, we hope you make better choices then robbing a bank with all the norepinephrine in your system.)

Instead, you should focus that heightened sense of determination and mental drive on your fat loss and athletic goals.

In addition, N-methyltyramine is a competitive substrate of monoamine oxidase (MAO) enzymes, meaning it can prolong the activity of monoamine neurotransmitters like dopamine, serotonin, adrenaline, and noradrenaline.[5] Hence, NMT often produces mood benefits and can help regulate appetite.

However, be cautious if you currently take an MAO inhibitor for a clinical condition while using NMT as the two would have an additive effect that could lead to neurotoxic levels of monoamine neurotransmitters in the body. (An example is serotonin syndrome, which is a potentially fatal condition.)

N-Methyltyramine Physical Benefits

As part of the stimulating properties NMT has on the nervous system and noradrenaline levels, your heart rate and muscle contraction capacity both increase. In turn, this can help you train harder, more intensely, and longer.

Moreover, NMT is postulated to promote lipolysis (fat breakdown) via noradrenaline and possibly other catecholamines. The data is rather limited and controversial regarding NMT and its direct effects of fat loss, with some studies suggesting it actually increases appetite and blocks lipolytic pathways.[6]

Nevertheless, the stimulatory benefits of NMT work well for the majority of people and may outweigh any anti-lipolytic actions it has. Most of the extant research has been in vitro or in mice, so hopefully, studies in the coming years will investigate the precise physiological mechanisms NMT works through in humans when it comes to fat loss and weight management.

NMT-Induced Fight-or-Flight Response for Bodybuilding and Fitness

As alluded to earlier, being in a fight-or-flight state enables you to accomplish physical feats that you never knew you were capable of. Imagine you’re being crushed by a 200-lb rock and gasping for air, but you normally can only bench 150 lbs for one rep at the gym.

In such a dire circumstance, your body is going to do everything it can to help you survive, and the fight-or-flight response might just be enough to help you push that massive rock off of your chest so you can escape an otherwise fatal situation.

Supplementing with NMT will help you reach new physical capacities by forcing your body to enter fight-or-flight state physiologically.   Naturally, the best time to take NMT is pre-workout since that’s right before you’re going to be pushing your limits physically/athletically. Regardless if you’re training with weights, doing cardio, or participating in an athletic event, NMT can help propel your performance.

It will also help you focus so that you can ignore the discomfort of an intense workout and hopefully break some long-standing personal records!

Be aware that the World Anti-Doping Agency (WADA) has banned PEA and its derivatives as of 2015. If you’re competing in any sort of bodybuilding or athletic organizations, always be sure to consult with their specific banned substance list to make sure NMT is approved for use, otherwise, you may fail a drug test.

Extended Benefits of NMT Supplementation

Since NMT is a vasopressor, it may be used to treat hypotension (low blood pressure). It also stimulates gastrin, a peptide that promotes gastric acid secretion.[7] In turn, N-methyltyramine may be useful for conditions like hypochlorhydria and indigestion.

Where to Buy N-Methyltyramine?

The two best places to buy N-methyltyramine are on the Vaxxen Labs Store or through other online vendors. It is quite uncommon to find an NMT supplement offline unless you’re shopping at a supplement store, like Vitamin Shoppe or GNC.

Vaxxen Labs

You can find an evidence-based dose of NMT in Cinerate – a comprehensive thermogenic supplement that contains a synergistic blend of fat-loss and energy-boosting ingredients. We recommend starting with one serving about 30 minutes before you exercise, especially if you’re doing cardio as this will help maximize the lipolytic effects of Cinerate.

Online Vendors

Some people are determined to purchase their own supplement ingredients and create their own weight loss cocktails containing N-methyltyramine. There is nothing wrong with this route so long as you’ve done your research and know what you can and can not combine when concocting your own thermogenic supplement.

In fact, buying ingredients in bulk individually on the internet is probably the most cost-effective way to get the results that you want. The tricky part is finding reliable sources for the ingredients as many companies import low-grade raw materials from overseas.

You also need to be cautious when it comes to combining different stimulants, like NMT, octopamine, caffeine, yohimbine, etc. Remember that NMT is a competitive substrate for MAO enzymes, meaning you don’t want to combine it with large amounts of dopaminergic, adrenergic, or serotonergic ingredients.

N-Methyltyramine Side Effects

In regular doses (i.e. 200 mg or less per day), NMT is virtually free from side effects and innocuous. The most common “side effect” is a more rapid heartbeat, but for most gym-goers, this is a desirable outcome.

Intuitively, you should not use NMT if you have cardiovascular issues as it may exacerbate your symptoms. Moreover, since N-methyltyramine is a vasopressor, you should not use it if you have high blood pressure or high cholesterol.

Be Careful

While supplement stacking is one of the best ways to help you achieve new bodybuilding and fitness goals, we also want you to be aware that randomly mixing ingredients like N-methyltyramine with others can be dangerous. Due to its adrenergic nature and stimulatory actions, NMT can modulate the properties of other compounds.

In particular, you should not combine NMT with any prescription MAOI as this can lead to excessive levels of monoamine neurotransmitters in the body.

Again, this is why you’re often better off simply buying a well-formulated supplement that suits your goals. We carefully crafted Cinerate so that you can avoid any harsh ingredient interactions while reaping the most benefit.

 

References

  1. T. A. Smith (1977). “Phenethylamine and related compounds in plants.” Phytochemistry 16 9 – 18.
  2. >Evans, C. S., & Bell, E. A. (1980). Neuroactive plant amino acids and amines. Trends in Neurosciences, 3(3), 70-72.
  3. Tsutsumi, E., Kanai, S., Ohta, M., Suwa, Y., & Miyasaka, K. (2010). Stimulatory Effect of N‐Methyltyramine, a Congener of Beer, on Pancreatic Secretion in Conscious Rats. Alcoholism: Clinical and Experimental Research, 34, S14-S17.
  4. Evans, C. S., Bell, E. A., & Johnson, E. S. (1979). N-methyltyramine, a biologically active amine in Acacia seeds. Phytochemistry, 18(12), 2022-2023.
  5. Gainetdinov, R. R., Hoener, M. C., & Berry, M. D. (2018). Trace amines and their receptors. Pharmacological Reviews, 70(3), 549-620.
  6. Stohs, S. J., & Hartman, M. J. (2015). A review of the receptor binding and pharmacological effects of N‐methyltyramine. Phytotherapy research, 29(1), 14-16.
  7. Yokoo, Y. O. S. H. I. A. K. I., Kohda, H. I. R. O. F. U. M. I., Kusumoto, A., Naoki, H. I. D. E. O., Matsumoto, N. O. B. U. Y. A., Amachi, T. E. R. U. O., … & Nukaya, H. A. R. U. O. (1999). Isolation from beer and structural determination of a potent stimulant of gastrin release. Alcohol and alcoholism (Oxford, Oxfordshire), 34(2), 161-168.
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