Grape Seed Extract Side Effects I Should Know About

grape seed extract side effects

In an attempt to build on a blog post we made a couple of months back about the benefits of grape seed extract we’re going to discuss some of the most common grape seed extract side effects our readers tend to see while supplementing.  Additionally, we’re going to review why you would be interested in adding grape seed extract to your macros and supplementation plan. Hopefully at the end of this blog post you’ll be an expert in grape seed extract properties. –Bet that was an achievement you never thought you’d hit in your life!

Side Effects of Grape Seed Extract

Let’s be clear here; Any of the side effects that you may be fearing are super rare.  Grape seed extract comes from grapes.  I know, shocker.  Each and every one of you, whether you like the taste or not, have had grapes at least a few times in your life.  Did you die?  Obviously not as you’re reading this post.  The most common side effects for individuals experimenting with grape seed extract supplementation are those who are allergic to grapes.  This begs the question:  Why would you try to supplement with grape seed extract, presumably knowing that you’re allergic to grapes?  We don’t know, but we can tell you that it has happened so, a disclaimer:  You WILL get sick and possibly have a severe reaction to grape seed extract supplementation if you are allergic to grapes that you’d buy from your local grocery store.

Now that we got that silliness out of the way, let’s look at the side effects the rest of us need to be aware of.  Grapes can cause people with bleeding disorders to really struggle with clotting.  If you have an iron deficiency or bleeding disorder, consult with your family physician before adding grape seed extract to your supplementation regimen.  Similarly, if you struggle with high blood pressure of have had a history of heart disease, please consult with the physician to see if your ticker is healthy enough to leverage grape seed extract’s antioxidants to benefit your system [1].  Avoid taking grape seed extract if you are on blood thinners or intend on having surgery in the near future.

Don’t Forget This if You Take Grape Seed Extract

If you start to take grape seed extract as a supplement to raise the level of antioxidants in your body, make sure that you inform your doctor during your next check up [2].  He or she will let you know whether or not there is any reason you shouldn’t be supplementing with it.

Pregnant women should avoid taking grape seed extract for a couple of reasons.  The first, you don’t know how the unborn child will accept it.  Just because you’re not allergic doesn’t mean your child isn’t allergic.  Some allergies are genetic but not all.  Secondly, you’re going to give birth!  We already know that supplementing with grape seed extract will make it more difficult for your blood to clot so why would you knowingly put yourself at risk?  Having a child isn’t unlike having a minor surgery.

Aside from the potentially negative side effects, there is no good excuse for you to not purchase and try grape seed extract.  It’s relatively cheap and can come in a variety of forms such as tablets, capsules, and liquids.  We suggest putting a few drops of the liquid extract in your protein drink.  You won’t even notice it!


  1. Haili Zhang, MM,a Shuang Liu, MM,b Lan Li, BD,b Shisong Liu, BD,b Shuqi Liu, MD,b,∗ Jia Mi, MD, PhD,c,∗ and Geng Tian, MD, PhDc,∗
    The impact of grape seed extract treatment on blood pressure changes
    Medicine (Baltimore). 2016 Aug; 95(33): e4247.
    Published online 2016 Aug 19. doi: 10.1097/MD.0000000000004247
  2. Yonguc GN1, Dodurga Y2, Adiguzel E3, Gundogdu G4, Kucukatay V4, Ozbal S5, Yilmaz I6, Cankurt U5, Yilmaz Y7, Akdogan I3.
    Grape seed extract has superior beneficial effects than vitamin E on oxidative stress and apoptosis in the hippocampus of streptozotocin induced diabetic rats.
    Gene. 2015 Jan 25;555(2):119-26. doi: 10.1016/j.gene.2014.10.052. Epub 2014 Oct 30.
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