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Alpha GPC Side Effects

Alpha GPC
Last modified: January 14th, 2019 06:24 am

Alpha-glycerylphosphorylcholine, or Alpha GPC, is a chemical naturally released as the fatty acids found in plants breaks down and is oxidized.  Primarily, we capture this chemical to utilize it in medicine.  There are powders, pills, and even straight liquid shots that people around the world use to consume the Alpha GPC.  The common thought is that Alpha GPC can be leveraged to improve neurological conditions [1], but that’s not way we are interested today.  Alpha GPC is a sexy new dietary supplement taking the body building world by storm.

Why Alpha GPC?

Fitness freaks around the world have been using Alpha GPC on the regular because it enhances and increases the level of growth hormone naturally found in the human body.  Not only has this been proven, but the results are absolutely stunning.  High doses of Alpha GPC have been taking the world of professional and competitive sports by storm because it’s much harder to detect than other performance enhancing drugs [2].

In addition to the growth hormone secretion, the same study proved that Alpha GPC promoted fat oxidation in the trial members, meaning you’re literally able to lose fat while gaining muscle.  Combine that with the usual workout regimen and other supplementation and it’s no wonder you get the pasty, pudgy, or wirey college athletes that look like The Hulk after just 2 years in the NBA or NFL.

We obviously don’t suggest you consider loading up on the Alpha GPC.  Too much of a good thing is usually a bad thing.  Our Fulcrum product already has a good portion of Alpha GPC for most people so if you’ve been able to take advantage of Fulcrum, you’re already benefiting from the Alpha GPC.  Mixing the Alpha GPC with the other ingredients in the pre workout shake exponentially improves the quality of workout you’re receiving.

In the world of medicine, Alpha GPC is usually used to treat serious neurological diseases or disorders like in those individuals suffering from Alzheimer’s disease or the aftermath of a stroke [3].  The growth hormone can help rebuild damaged neurosensory and brain cells, slowing the effects of the disease or disorder.

Side Effects of Alpha GPC

If you’re a regular reader to this blog then you can probably name the most common side effects for the different ingredients in our supplements.  Alpha GPC is no different in that the only real side effects are more annoying than health threatening.  In ascending order of importance, here are the top six side effects found to be associated with Alpha GPC consumption:

  1. Heartburn – This is actually not that common of a side effect when it comes to our other ingredients but heartburn is the most common side effect reported from those who are treated with Alpha GPC.
  2. Headache – A side effect reported by users of all supplements. Your body struggles to get used to new chemical levels but eventually this passes without issue.
  3. Skin Rash.
  4. Confusion – This one is another new one. It makes sense though when you consider that the substance messes with the chemical balances in your brain.  Confusion has always been reported to be temporary, like if you awake suddenly from a deep sleep.

If you’re concerned about the effects or properties of Alpha GPC, just ask your physician if it’s something that is okay for you.


  1. Adam G Parker,corresponding author1 Allyn Byars,1 Martin Purpura,2 and Ralf Jäger2
    The effects of alpha-glycerylphosphorylcholine, caffeine or placebo on markers of mood, cognitive function, power, speed, and agility
    J Int Soc Sports Nutr. 2015; 12(Suppl 1): P41.
    Published online 2015 Sep 21. doi: 10.1186/1550-2783-12-S1-P41
  2. Kawamura T1, Okubo T, Sato K, Fujita S, Goto K, Hamaoka T, Iemitsu M.
    Glycerophosphocholine enhances growth hormone secretion and fat oxidation in young adults.
    Nutrition. 2012 Nov-Dec;28(11-12):1122-6. doi: 10.1016/j.nut.2012.02.011. Epub 2012 Jun 5.
  3. Philip A. DeFina, 1 Rosemarie Scolaro Moser, 2 ,* Megan Glenn, 2 Jonathan D. Lichtenstein, 2 and Jonathan Fellus
    Alzheimer’s Disease Clinical and Research Update for Health Care Practitioners
    J Aging Res. 2013; 2013: 207178.
    Published online 2013 Sep 4. doi: 10.1155/2013/207178

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Matt Weik, the owner of Weik Fitness, LLC, is a well-respected fitness expert/author/podcaster with a global following. His work has been featured in nearly 100 fitness magazines (Flex Magazine, Men’s Muscle & Health Magazine, Oxygen Magazine), 2,000+ websites, as well as having numerous books and audiobooks that are published.  Matt Weik graduated from Penn State University with a degree in Kinesiology. He is a certified strength and conditioning specialist, personal trainer, and sports nutritionist. Matt is a member of the supplement expert panel at the Awards 2018.

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