Agmatine Sulfate Side Effects

agmatine sulfate side effects

Since we’ve been talking about agmatine sulfate lately, we figured we better touch on the side effects.  There are only three known side effects that you need to be aware of when considering agmatine sulfate as a supplement.  None of them are too concerning and the most common and significant side effect is not even a real problem for most people [1].  We don’t want to be misleading so when we say “most common” we mean “almost everybody experiences it.”  Before reading on and learning about the three agmatine sulfate side effects, you might want to review the benefits of taking agmatine sulfate and where you can get it.

#1 Agmatine Sulfate Side Effect by Far… Hungry? 

You will be!

If you’re trying to burn fat and lose weight, definitely don’t add any agmatine sulfate to your supplement rotation.  This is the side effect that nearly everybody experiences.  When you’re supplementing with agmatine sulfate, you’re going to be hungry.  Often.  Increased appetite can be seen as a benefit if you’re looking to bulk up and put on some pounds but not if you’re trying to shed weight and gain lean muscle [2].

If you think you have the willpower to fight through almost constant hunger without giving in, go ahead and take agmatine sulfate during a fat loss diet.  Assuming you don’t give in, the agmatine sulfate is going to boost the muscle gains without having your visceral fatty deposits grow.  Just understand that you’re going to be suffering from hunger pangs early and often as increased appetite is to be expected!

#2 … Nausea and Gas

Not everybody suffers from the gastrointestinal problems that arise from agmatine sulfate supplementation, but a fair bit of unfortunate souls do.  Coming in at number two on our list, nausea and gas can be experienced, especially during the first couple of weeks of supplementation.  Since agmatine improves your digestive system by cleaning you out and clearing out leftover toxins from garbage food, your stomach and intestines will be working overtime for a short period.  Once your system gets up to snuff, the nausea and gas will subside and you’ll be enjoying your new “regular.” [3]

#3 … Low Blood Pressure

Far less common than the first two side effects we talked about, low blood pressure has been found to be related to agmatine sulfate supplementation.  People who already struggle with low blood pressure should avoid agmatine altogether.  Everybody else just needs to be aware that it could potentially cause problems if you’re going to have some sort of surgery.  Clotting can be an issue when your skin tries to scab over and repair itself, should you get a cut.  There are certain all natural supplements out on the market that you can use to combat hypotension and low blood pressure.  The number of individuals that experience low blood pressure due to agmatine sulfate is relatively low so we don’t suggest that you let this potential side effect deter you from adding it to your daily macros [4].


  1. Gilad GM1, Gilad VH.
    Long-term (5 years), high daily dosage of dietary agmatine–evidence of safety: a case report.
    J Med Food. 2014 Nov;17(11):1256-9. doi: 10.1089/jmf.2014.0026. Epub 2014 Sep 23.
  2. Prasad A1, Prasad C.
    Agmatine enhances caloric intake and dietary carbohydrate preference in satiated rats.
    Physiol Behav. 1996 Oct;60(4):1187-9.
  3. Keynan O1, Mirovsky Y, Dekel S, Gilad VH, Gilad GM.
    Safety and Efficacy of Dietary Agmatine Sulfate in Lumbar Disc-associated Radiculopathy. An Open-label, Dose-escalating Study Followed by a Randomized, Double-blind, Placebo-controlled Trial.
    Pain Med. 2010 Mar;11(3):356-68. doi: 10.1111/j.1526-4637.2010.00808.x.
  4. Raasch W1, Schäfer U, Qadri F, Dominiak P.
    Agmatine, an endogenous ligand at imidazoline binding sites, does not antagonize the clonidine-mediated blood pressure reaction.
    Br J Pharmacol. 2002 Feb;135(3):663-72.
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